谷氨酸转运体与缺血性脑损伤

Glutamate transporters and ischemic brain injury

背景缺血性脑损伤严重威胁人类的生命健康，谷氨酸损伤在缺血性脑损伤的疾病进展中起重要作用，调控谷氨酸浓度对缺血性脑损伤的治疗具有重要意义。目的探讨缺皿性脑损伤与谷氨酸转运体的关系及多种预处理方法对谷氨酸转运体的影响，寻找一种缺血性脑损伤的治疗方法。内容综述谷氨酸转运体的亚型、分布、结构和功能以及谷氨酸转运体与缺血性脑损伤和多种预处理神经保护作用的关系。趋向非缺血预处理如电针预处理、高压氧预处理等对脑缺血损伤治疗效果确实且易于实施，谷氨酸转运体可能是其产生保护作用的机制之一。

Background Ischemia brain injury seriously threatens human life and health. Glutamate plays a major role in the pathogenesis of ischemia brain injury, and the regulation of glutamate concentration on the treatment of ischemic brain injury is important. Objective To find a treatment of ischemia brain injury, we investigate the relationship between brain ischemia injury＇ and glutamate transporters, and the effect of a variety of pretreatments on glutamate transporters. Content This review summarizes the glutamate transporterJs subtype, distribution, structure and function, and the relationship with ischemic brain injury and the neuroproteetive effect of pretreatments. Trend Non-isehemie pretreatment, such as electroacupuncture pretreatment and hyperbaric oxygen pretreatment of cerebral ischemia, is effective and easy to implement. Glutamate transporters would be one of the protective mechanisms.