白三烯A4水解酶功能调节剂(E)-2-(1-羟基-4-环己酮)乙基咖啡酸酯的全合成研究

Total Synthesis of Natural Product(+)-2-(1-Hydroxyl-4-oxocyclohexyl)ethyl Caffeate as a Modulator of Leukotriene A4 Hydrolase

以1,4-环己二酮单乙二醇缩酮和咖啡酸为起始原料,经两条不同的路线完成了(E)-2-(1-羟基-4-环己酮)乙基咖啡酸酯的全合成,并确定了其最佳合成路线,总收率达56%.

（＋）-2-（1-Hydroxyl-4-oxocyclohexyl）ethyl caffeate （1）, a new caffeate was first synthesized starting from 1,4-cyclohexanedione monoethyleneketal and caffeic acid through two different routes. The optimum synthetic route was determined, under which the final yield was 56%.