摘要
目的:为探讨黏蛋白1(mucin1,MUC1)表达对胃癌发生、发展、转移的影响,笔者检测了MUC1在转化的人正常胃黏膜细胞系(GES-1)和低分化胃腺癌细胞系(BGC-823)中的表达情况,分析其表达的临床意义。方法:应用间接免疫荧光法检测MUC1在GES-1和BGC-823中的表达和定位。结果:MUC1在GES-1和BGC-823中的表达,差异有统计学意义(P<0.05)。结论:MUC1在肿瘤的发生、发展中发挥一定作用。MUC1可能与胃癌恶性的进展和转移有关,在胃癌的发生、发展过程发挥着重要作用。
Objective： To study the effect of the expression of Mucin 1（MUC1） on occurrence and development of gastric can cer,the expression of MUC1 in normal cell lines of gastric mucosa（GES-1） and cell lines of poorly differentiated gastric ade nocarcinoma（BGC-823） were researched,and then their clinical significance were analyzed.Methods： Indirect immunofluorescence was used to investigate the expression and location of MUC1 proteins in GES-1 and BGC-823.Results： The expressions of MUC1 were significantly different between GES-1 and BGC-823（P0.05）.Conclusion： The MUC1 plays a role in occurrence,development and metastasis of gastric cancer.MUC1 may play an important role in the development and metastasis of gastric cancer.
出处
《中国医药导报》
CAS
2011年第35期191-192,共2页
China Medical Herald
关键词
胃癌
黏蛋白1
间接免疫荧光
Gastric cancer
Mucin 1
Indirect immunofluorescence
