定量检测血清降钙素原对肺部感染患者的诊断意义

Diagnostic value of quantitative measurement of serum procalcitonin in patients with lung infection

目的探讨血清降钙素原(PCT)检测在肺部感染诊断中的意义。方法采用PCT双抗体夹心定量荧光免疫分析仪,对60例肺感染患者和30例健康体检者进行PCT定量检测,并作相关比较分析。结果患者组PCT明显高于健康对照组,与胸部X线诊断符合率为83%,与细菌培养阳性结果符合率为62%,与WBC升高符合率达100%。荧光双抗体夹心定量PCT检测可用于细菌感染的早期诊断,该检测快速方便,早于传统细菌培养、胸部X线检查和C-反应蛋白检测。结论血清降钙素原是临床鉴定细菌感染的新指标并可指导临床合理使用抗生素。

Objective To explore the significance of the serum procalcitonin （PCT） detection for the diagnosis of lung infection. Methods Serum PCT level of 60 patients with pulmonary infection and 30 healthy controls were detected by using ELISA quantitative fluorescence immunity analyzer. Results The serum PCT level in patient group was obviously higher than in control group, with the coincidence of 83% ,62% and 100% ,compared with chest X ray diagnosis,positive results of germiculture and the increase of WBC level. Fluorescence ELISA quantitative PCT test could be used for the early diagnosis of bacterial infection with faster detecting speed,compared with traditional bacteria cultivation, chest X-ray detection and C-reactive protein detection. Conclusion PCT could be a new indicator for the clinical identification of bacteria infection and could guide the reasonable choice of antibiotics in clinical practice.