腔隙性脑梗死患者抑郁状态相关因素的回归分析

Risk factors for developing depression after first-ever lacunar infarction:a logistic analysis

目的对腔隙性脑梗死后抑郁(PSD)患者进行多种相关因素的研究,为PSD患者早期诊断和干预治疗提供依据。方法采用病例-对照研究方法,选用符合标准的2010年1月至2011年4月住院的所有初发腔隙性脑梗死患者,其中抑郁患者为病例组,其余患者为对照组,对研究资料先进行单因素分析,然后进行多因素非条件Logistic多元回归分析。结果 138例患者中能够完成所有调查任务的123例,其中抑郁病患者43例。经分析筛选神经功能缺损评分、病灶数量、基底节区病变3个因素为PSD的危险因素,受教育程度为PSD的保护因素。结论神经功能缺损程度为PSD最重要的危险因素,受较高水平教育为PSD的保护因素。

Objective To investigate various correlation factors associated with post-stroke depression（PSD）,and provide a basis for early diagnosis and intervention of PSD.Methods A case-control study was used.Eligible hospitalized stroke patients with first-ever lacunar infarction from January 2010 to April 2011 were divided into the depression group and the control group.Multivariate unconditional logistic regression analysis was made after single variable analysis.Results 138 patients were surveyed,among whom 123 completed all the investigations.The overall incidence of PSD was 35%（43 cases）.The following four factors were associated with PSD,severity of neurological deficits,number of lacunar infarcts and basal ganglia lesions as risk factors,and level of education as the protective factor.Conclusion The severity of neurological impairment is the most important risk factor for PSD,whereas,good education is the protective factor.