哒嗪酮苷类化合物的合成研究

Research on the Syntheses of Substituled Pyridazinone Nucleosides

一些嘧啶系列的苷具有较强的生理活性,其中5-氟脲苷是有效的抗癌药物。而哒嗪与嘧啶具有同分异构关系,那么,哒嗪苷类化合物是否也有相似的生理活性呢?六十年代初,Wagner等开展了这一领域的研究;到七十年代中期。

In this paper, we have reported the syntheses of some new substituted pyridazinonenucleosides. They are new compound, of which the IR, ~1H NMR, UV, MS and elementaryanalysis were presented.