女性难治性抑郁症的共病情况与患病风险

The study of characteristics of treatment-resistant depression in women

目的了解女性难治性抑郁症临床特征,包括共病情况与患病风险。方法采用复合国际诊断访谈与自评式问卷调查方式,选取103例女性单相抑郁症患者,其中难治性抑郁症患者组30例和非难治性抑郁症患者组73例。结果女性难治性抑郁症患者组与非难治性抑郁症患者组相比,起病年龄早、总病程长、发作次数多;在广泛性焦虑障碍、心境恶劣的共病率,经前期综合征、EPQ神经质维度、生活应激事件、父母亲情关系量表母亲控制维度平均分,均高于非难治性抑郁症患者,存在显著性差异(P均<0.05或P<0.01);两组在惊恐障碍、恐怖症、产后抑郁症症、家族史、儿童期性侵犯的共病率比较,父母亲情关系量表父亲控制维度、父母亲照顾维度平均分比较,均无显著差异(P>0.05)。结论女性难治性抑郁症存在起病年龄早、总病程长、发作次数多,与广泛性焦虑障碍、心境恶劣共病率高,经前期紧张症状多,具有神经质的人格特征,生活应激明显。

Objective To investigate the clinical characteristics of treatment-resistant depression（TRD） in women,including comorbidity and risk factors for depression.Methods To enroll 103 unipolar depressive women patients,including 30 patients with TRD and 73 patients with non-TRD,used the world mental health composite international diagnostic interview questionnaire（CIDI） and self rating questionnaire in the study.Results Compared to non-TRD group,TRD group had younger first onset age,longer course of disease,more times of onset,higher comorbidity with generalized anxiety disorder（GAD） and dysthymia,more Pre-Menstrual Syndrome,higher s core in mother control dimensionality in Parental Bonding Instrument（PBI）,higher neuroticism score in Eysenck personality questionnaire and more stress life events than non-TRD,they have statistical significance（P〈0.05 or P〈0.01）.There was no significant difference in comorbidity with panic disorder and phobia disorder,morbidity with postpartum depression,depression family history,father control dimensionality,father and mother tendance dimensionality in PBI,child sexual abuse（P〉0.05）.Conclusion The women patients with treatment-resistant depression have younger first onset age,longer course of disease,more times of onset,higher comorbidity with generalized anxiety disorder （GAD） and dysthymia,more Pre-Menstrual Syndrome,Neuroticism and more stress life events.