孕妇血型抗体监测在ABO-HDN预防中的意义

Maternal blood group antibodies monitoring in prevention of ABO-HDN

目的研究孕妇血型IgG抗体效价监测在预防新生儿ABO溶血病(ABO-HDN)中的价值。方法采用改良抗人球蛋白法监测938例O型血孕妇血清IgG抗体效价并对高风险新生儿做ABO-HDN血清学检测。结果孕妇血清抗体效价为1∶64、1∶128和≥1∶256时,新生儿ABO溶血病的发病率分别为10.24%、43.24%、89.47%,不同抗体效价组别间差异有统计学意义。结论孕妇血型抗体效价与ABO-HDN的发病率呈正相关,对ABO-HDN的预防具有重要意义。

Objective To study the value of maternal blood group IgG antibody titer monitoring in prevention of ABO hemolytic disease of newborn （ABO-HDN）.Methods To monitor sera IgG anti-（A） B antibody 938 cases of pregnant women with blood type O using improved anti-human globulin method and serological detection of hemolytic disease on high-risk newborns.Results When the valence of antibody was 1∶64,1∶128,1∶256 and more,the ABO-HDN incidence rates were 10.24%,43.24%,89.47% respectively.Statistically significants were detected between different antibody titers groups.Conclusion The more the titers of IgG andbody in the sera with pregnant women,the higher the incidence of ABO- HDN were.So the blood group IgG antibody titers monitoring were very important to the prevention of ABO-HDN in pregnance.