复胃散治疗慢性萎缩性胃炎的临床研究

Clinical research of Fuwei Powder in treating chronic atrophic gastritis

目的观察复胃散治疗慢性萎缩性胃炎癌前病变的疗效并探讨其可能的作用机理。方法 60例患者随机分为两组,治疗组予以自拟复胃散治疗,每次9 g,每日2次,3个月为一疗程,治疗1～2个疗程。对照组予以奥美拉唑(Omeprazole)10 mg,每日1次;果胶铋100 mg,每日3次。1个月为一疗程,治疗1～2个疗程。主要观察两组患者服药前后主要症状改善情况,胃镜及病理组织学变化情况及Hp清除情况。结果两组治疗CAG的临床总有效率、胃镜有效率、腺体萎缩治疗有效率、肠上皮化生和不典型增生治疗有效率对比有显著性差异(P<0.05);Hp感染治疗有效率对比无显著性差异(P>0.05)。结论复胃散可明显改善患者的临床症状,对患者胃黏膜镜下改变、病理改变(肠上皮化生、不典型增生)有一定的逆转作用,有一定的抗Hp感染作用。

Objective： To investigate the effects and mechanism of Fuwei Powder on patients who had precancerous lesions of chronic atrophie gastritis （CAG）. Methods ： Sixty patients with CAG were randomly divided into the treatment group and control group, with 30 cases in each group. The treatment group was treated by Fuwei Powder, and the control group was treated by Omeprazole and Pectin Bismuth. The eourse of the treatment group lasted three months and that of the control group one months. Results ： There was a significant difference in improving the pathologieal ehange of atrophy, intestinal metaplasia （ IM ） between the two groups （ P 〈 0.05 ） , but no significant difference in improving Helieobaeter Pylori （Hp） （P 〉 0.05 ）. Conclusion： Fuwei Powder is better than Omeprazole and Pectin Bismuth in improving clinical symptoms, living quality of patients with CAG. Fuwei Powder can reverse the gastro - scope and histology of the patients with CAG and has an effect on anti -Hp in some degree.