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BMP-12联合自体骨髓间充质干细胞(BMSCs)藻酸钙载体复合物移植修复兔软骨缺损

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摘要 目的 观察BMP-12诱导的BMSCs移植修复兔软骨缺损的效果,试图发现有效治疗软骨缺损的策略.方法 新西兰大白兔20只,兔龄3个月,体重2kg左右,左、右膝关节造成软骨缺损模型,左膝为实验组(A组),右膝为对照组(B组),将含有BMP-12的BMSCs藻酸钙载体复合物植入A组,将BMSCs藻酸钙载体复合物植入B组.结果 A,B组软骨缺损处均被透明软骨充填,A组透明软骨数量多于B组,随时间后移,缺损处被填充的越充分,A组填充的软骨细胞具有明显的陷窝且功能旺盛.结论 BMSCs可作为软骨缺损的组织工程种子细胞,BMP可加速诱导其分化为软骨细胞.
作者 张艳 黄云鹏
出处 《实用手外科杂志》 2011年第3期259-259,共1页 Journal of Practical Hand Surgery
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