摘要
An efficient one-pot synthesis of 5-（trifluoromethyl）-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-l,2,4-triazole and ethyl 4,4,4-trifluoro-3- oxobutanoate or 4,4,4-trifluoro-l-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, mild reaction conditions, high yields and eco-friendliness.
An efficient one-pot synthesis of 5-（trifluoromethyl）-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-l,2,4-triazole and ethyl 4,4,4-trifluoro-3- oxobutanoate or 4,4,4-trifluoro-l-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, mild reaction conditions, high yields and eco-friendliness.
基金
Project supported by the National Natural Science Foundation of China （No. 200810102050）, the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions （No. 09KJA430003）, the Natural Science Foundation of Xuzhou City （No. XM09B016）, Graduate Foundation of Xuzhou Normal University （No. 2010YLB029） and Qing Lan Project （No. 08QLT001）.
