摘要
A Pd（II） catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon-palladium bond by protonolysis to regenerate the Pd（II） species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.
A Pd（II） catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon-palladium bond by protonolysis to regenerate the Pd（II） species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.
基金
Project supported by the National Basic Research Program of China （No. 2009CB825300） and the Natural Science Foundation of China （Nos. 20732005, 20872158）.
