摘要
The reaction of chiral N-（tert-butanesulfinyl）ketimines and α,β-unsaturated trifluorotuethyl ketones catalyzed by DBU was achieved under mild conditions. 1,2-Addition products, precursors of chiral trifluoromethylated 1,3-amino alcohols, were obtained diastereoselectively （dr value up to 95 ： 5） in moderate yields （up to 76%）. A possible catalytic cycle was proposed.
The reaction of chiral N-（tert-butanesulfinyl）ketimines and α,β-unsaturated trifluorotuethyl ketones catalyzed by DBU was achieved under mild conditions. 1,2-Addition products, precursors of chiral trifluoromethylated 1,3-amino alcohols, were obtained diastereoselectively （dr value up to 95 ： 5） in moderate yields （up to 76%）. A possible catalytic cycle was proposed.
基金
Project supported by the National Natural Science Foundation of China （No. 20872166）.
