摘要
indazolo 的新、有效的串联合成[2,1-a ] indazole-6,12-diones 被开发了。这个协议包括联合反应的催化铜的 intramolecular CN 跟随的分子间的 N-acylation。方法论被用于大量 2-bromo 和 2-chloro benzoyl 氯化物产出 indazolo-[2,1-a ] indazole-6,12-diones 在对有高 regioselectivities 的优秀收益好。
A new and efficient cascade synthesis of indazolo[2,1-a]indazole-6,12-diones has been developed. This protocol includes an intermolecular N-acylation followed by a copper-catalyzed intramolecular C--N coupling reaction. The methodology is applied to a wide range of 2-bromo and 2-chloro benzoyl chlorides to yield the indazolo- [2,1-a]indazole-6,l 2-diones in good to excellent yields with high regioselectivities.
基金
Project supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the National Natural Science Foundation of China （Nos. 21072168, 21102009） and Natural Science Foundation of Jiangsu Province （No. BK2011230）.
关键词
区域选择性
有效合成
铜催化
二酮
酰化
级联
进程
环化
Indazolone derivatives, cascade reaction, copper（I） catalyst, 2-halobenzoyl chlorides
