液基薄片技术在呼吸道细胞病理学诊断中的应用

The Application of ThinPrep Cytology Test in the Diagnosis of Respiratory Cytology

目的探讨液基薄片技术(ThinPrep cytology test,TCT)在呼吸道细胞病理学诊断中的应用。方法收集257例呼吸道细胞学检查标本,运用TCT技术进行制片,统计阳性率,并与传统离心沉淀呼吸道细胞涂片126例病理诊断结果相比较。结果 TCT涂片背景清晰,收集细胞较多,细胞形态保持较好,细胞分布比较均匀,细胞重叠较传统涂片大大减少。TCT方法与传统涂片组相比,病变检出率显著提高,两组相比有显著统计学差别。结论液基薄片技术在呼吸道细胞学检查运用中能获得高质量涂片,细胞形态改变显示清楚,同时又可辅以免疫组织化学染色,与传统涂片相比,大大提高了呼吸道细胞学检查的准确性和阳性率。

Objective To explore the value of ThinPrep cytology test in diagnosis of respiratory cell pathology. Methods A total of 257 samples from respiratory tract were made by TCT. Analyzing the positive rate, and comparing with 126 cases of conventional centrifugation respiratory tract pathological diagnosis. Results TCT smear has a dear background and more cells, good shape, well-distribution, and fewer overlap. TCT method compared with conventional smears, the lesion detection rate was significantly increased, there was significant statistical difference, Conclusion TCT showed the advantage in sensitivity or specificiw in respiratory cytopathological diagnosis by combining with immunohistochemical staining.