点阵激光联合湿润烧伤膏治疗痤疮凹陷性瘢痕疗效观察

Efficacy Observation of MEBO combined with Fractional Laser in the Treatment of Acne Pitting Scars

目的对比观察湿润烧伤膏治疗痤疮凹陷性瘢痕点阵激光术后创面的临床疗效。方法将64例痤疮凹陷性瘢痕患者随机分为治疗组32例和对照组32例,治疗组在点阵激光治疗后采用湿润烧伤膏治疗,对照组则在点阵激光治疗后采用红霉素眼膏治疗,对比观察两组术后疼痛程度、创面愈合时间及不良反应。结果治疗组显效11例,有效18例,无效3例,总有效率90.63%;对照组显效9例,有效19例,无效4例,总有效率87.50%,两组疗效比较差异无显著性(P>0.05)。患者随着治疗次数的增加,疗效逐渐提高,术后30min疼痛程度评分:治疗组为3.23±0.31,对照组为6.54±0.35,治疗组疼痛程度与对照组相比,差异有显著性意义(P<0.05);创面愈合时间:治疗组为5.24d±1.32d,对照组为9.94d±0.45d,治疗组创面愈合时间与对照组相比,差异有显著性意义(P<0.05)。术后治疗组出现暂时性色素沉着1例,红斑2例,对照组出现暂时性色素沉着2例,红斑3例,均1月内消退。两组创面均未见感染。结论点阵激光联合MEBO治疗痤疮凹陷性瘢痕疗效确切,安全性高,不良反应少,术后疼痛轻,创面愈合时间短,对患者的学习及工作影响小,值得临床推广应用。

Objective To comparatively observe the clinical efficacy of the Moist Exposed Burn Ointment （ MEBO） in the treatment of wound of acne pitting scars treated by fractional laser. Methods Sixty-four patients with ache pitting scars were randomly divided into the treatment group （ N = 32 ） and the control group （ N = 32 ）. The treatment group was Ireated with MEBO after fractional laser surgery, while the control group was treated wittl erythrnmycin eye ointment after fractional laser surgery. The indexes such as postoperative pain, wound healing time and adverse reaelion were comparatively observed. Results In the treatment group, 11 eases were markedly effeetive, 18 cases were effective and 3 were ineffective, with the tolal effective rate up to 90. 63%. However, in the control group, 9 eases were markedly effective, 19 cases were effective while 3 were ineffective, with the total effective rate being 87.50%. The difference between the two groups was not statistically significant （ P〉0. 05 ）. But the efficacy was gradually increased with the increase of the treatment times. The pain degree score at thirty minutes post-operation was 3.23＋0. 31 in treatment group while that was 6. 54±0. 35 in control group, the difference was statistically significant （ P〈0. 05 ）. The wound healing time was 5.24±1.32 days in the treatment group, while it was 9. 94±0. 45 days in the control group. The difference between the two groups was obviously significant （ P〈0. 05 ）. After treatment, temporary pigmentation occurred in one case of treatment group and 2 cases of control group, and erythema occurred in two cases of treatment group and 3 cases in control group. But all these symptoms disappeared in one month. No infection was observed in the two groups. Conclusion MEBO ointment combined with fractional laser is an effective and safe method in treating acne pitting scars, with few adverse reactions, light postoperative pain and short wound healing time as well as little influence to patients＇ life and work. Thus, it is worthy to be applied in clinic widely.