无症状人群血清同型半胱氨酸与冠状动脉病变程度关系的研究

Study of the Correlation Between Serum Homcystein and Degree of Stenosis by 64-slice Coronary Computed Tomography Angioplasty in Asymptomatic People

目的测定无症状人群血清同型半胱氨酸(HCY)水平,并与64层冠状动脉CT(MSCT)成像结果进行相关性分析。方法 252例行MSCT的无症状患者根据冠状动脉CT结果分为冠状动脉正常组、冠状动脉狭窄≤50%组及冠状动脉狭窄>50%组。采用Logistic回归分析对常见危险因素与冠状动脉狭窄程度进行分析,并测定三组HCY水平。结果结果表明,性别、低密度脂蛋白胆固醇(LDL-C)、吸烟、年龄、总胆固醇(TC)与冠状动脉粥样硬化引起的冠脉狭窄程度呈正相关;冠状动脉正常组血清HCY水平(10.38±2.31)μmol/L、冠状动脉狭窄≤50%组(13.45±2.86)μmol/L,冠状动脉狭窄>50%组(16.23±7.46)μmol/L,三组之间比较差异有显著性。结论吸烟、TC、LDL-C、性别和年龄与冠脉狭窄程度密切相关。HCY水平与冠状动脉狭窄程度呈正相关,冠状动脉狭窄>50%组血清HCY水平较冠状动脉正常组明显升高。在无症状人群中进行MSCT及HCY的筛查,对早期预防和诊断冠心病有重要临床意义。

Objective To investigate the relation between serum homeystein and the degree of coronary stenosis in asymptomatie people. Methods From March 2011 to June 2011,183 asymptomatie individuals underwent the exami- nation of coronary CTA. According to the results of CTA, the subjects were divided into 3 groups according to the degree of coronary stenosis. The concentration of the serum homcystein was measured. Results The degree of coronary stenosis was subjected to influences by gender,LDL-C, smoking,ageand total cholesterol （TC）. The levels of the serum homcystein were closely correlated to the degree of coronary stenosis. Conclusion The levels of the serum homcystein were closely correlated with the coronary atherosclerosis and its severity. Cardiac CTA and serum homcysteiu could be used as screening tools for clinical prevention, treatment and monitoring for coronary heart disease in asymptomatic individuals.