卡前列素氨丁三醇治疗孕产妇产后出血的临床观察

目的观察卡前列素氨丁三醇预防孕产妇产后出血的疗效。方法收集本院2008年1月～2011年2月收治的产后出血患者100例,随机分为两组,每组50例。对照组患者产后经宫体注射缩宫素20IU,效果欠佳者,加量静脉滴注缩宫素;治疗组患者产后同时给予缩宫素20IU和250μg卡前列素氨丁三醇,比较两组患者用药后止血时间、产后2h出血量、总有效率和不良反应的发生情况。结果治疗组的止血时间(15.3±3.5)min与对照组(35.5±7.6)min比较明显缩短;治疗组的出血量(164.3±10.6)mL与对照组的(267.6±15.5)mL也显著减少,差异具有统计学意义(P<0.05)。治疗组的总有效率为94.0%,而对照组为74.0%,差异有统计学意义(P<0.05)。结论卡前列素氨丁三醇可用于常规治疗宫缩乏力性产后出血患者疗效确切,具有安全高效等优点,不良反应少,值得临床进一步研究推广。

Objective To observe the carboprost tromethamine prevent pregnancy after maternal hemorrhage.Methods 100 patients with postpartum hemorrhage in the hospital from January 2008 to February 2011 were randomly divided into two groups ,each group 50 cases.The patients post by palace injection of oxytocin 20 IU, ineffective,plus the amount of intravenous infusion of oxytocin; postpartum treatment group, while giving oxytocin 20 IU and 250 μg Carboprost tromethamine, after treatment were compared in patients with bleeding time, 2 hours after bleeding, the total efficiency and the incidence of adverse reactions.Results Bleeding time the of treatment group was（15.3±3.5） min ,which significantly reduced compared with the control group （35.5±7.6） min ; blood loss of treatment group was（164.3±10.6） mL,which also significantly reduced compared with the control group （267.6±15.5） mL, the specific apparent statistical significance （P〈0.05）. In the treatment group, the total effective rate was 94.0%, while the control group was 74.0%, there was statistically significant between two groups（P〈0.05）. Conclusion Carboprost tromethamine can be used for routine treatment of postpartum hemorrhage by uterine inertia is effective, safe and efficient with the advantages of fewer adverse reactions, is worthy of further research and promotion.