高强度聚焦超声治疗恶性实体肿瘤

目的研究高强度聚焦超声(HIFU)治疗恶性实体肿瘤的有效性和安全性。方法应用FEP-BY01型高强度聚焦超声治疗118例中晚期肿瘤患者。根据患者身体状况、肿瘤特点及治疗顺应性等给予0.5～1.0kW的发射功率,治疗后进行临床受益率、近期疗效及安全性的分析。结果 118例患者中,其中CR0例(0%)、PR37例(31.4%)、SD47(39.8%)、PD23(19.5%)、近期总有效率31.4%(37/107);临床受益率为77.1%(91/118);毒副作用是轻微、可忍受的。结论术前评估患者肿瘤特征、适时调整治疗参数并联合其他治疗手段有助于提高近期疗效、减少并发症的产生。

Objective To investigate the efficacy and side effects of high intensity focused ultrasound （HIFU） in the treatment of malignant solid tumors. Methods 118 patients with advanced malignant tumors were designated as the candidates and were treated with FEP-BY01. The emission power of0.5-1 .SKW was applied to individuals according to physical conditions, tumor characteristics and compliance. Then clinical benefit response, recent curative effect and side effects were observed and analyzed. Results Of the 118 patients, complete remission （CR）was in zero （0%）, partial remission（PR）was in 37（31.4%）, stable disease（SD）was in 47（39.8%）, and progression disease（PD）was in 23 （19.5%）The total response rate was 31.4%（37/107） .The clinical benefit response was 77.1%（91/118）. The side effect is tolerable and mild. Conclusion Evaluation of physical conditions, tumor characteristics and compliance prior to HIFU as well as adjustment of the emission power parameters in therapy in combination with other subsecluent remedies contribute to the improvement of recent curative effects and the decrease of the incidence of comolications.