乳腺病变3646例冷冻切片诊断分析

Frozen section diagnosis in breast lesions-An analysis of 3646 cases

目的为提高乳腺病变冷冻切片诊断的正确性提供有参考价值的资料。方法就我科1991年～1995年间3646例乳腺病变的冷冻切片进行回顾性分析。结果发现乳腺病变的冷冻切片占冷冻切片总数的49．78％，居首位。对3646例乳腺病变的冷冻切片与石蜡切片对照比较，得出确诊率为99.23％，（其中完全符合98．65％，基本符合1．35％），未确诊率0．74％，误诊率0．027％。3646例病例中，良恶性病变之比为3．05：1。将本组统计资料与国内外同类资料进行了分析比较，总结讨论了我院确诊率较高的经验和产生误诊的原因及延迟诊断中存在的困难。结论肯定了冷冻切片诊断在乳腺病变诊断中的重要意义。

To improve the accuracy of frozen section (FS) diagnosis in breast lesions.Method A retrospectivereview was performed on 3646 consecutive FS cases of breast lesions from 1991 ~ 1995. Results In our data, FS diagnosis forbreast lesions is the most common one of all FS diagnosis (49. 78% ). Comparing the original FS diagnosis with the permanentparaffin section diagnosis,we found that the diagnosis was accurate 36l8 of 3646 cases (99.23% ) in which 98.65% was com-pletely consistent and 1 .34% was almost consistent. In 27 of 3646 cases (O.74% ) the diagnosis was not certain, while in l of3646 cases (0.027% ) the diagnosis was modified (false negative). Overall, the benign/malignant ratio was 3.05: l. The datawas compared with the same type of data in the literature, both domestic and abroad,and the factors affecting accuracy of FSdiagnosis in breast lesions were emphasized. Conclusion On the basis of our results,FS is considered as a fessible and reliablediagnostic procedure in breast lesions.