小儿胃镜及胃粘膜454例活检临床病理分析

A clinicopathological analysis of 454 children by gastroendoscopy and mucosa biopsy

目的探讨小儿胃粘膜活检的组织学特点及临床病理特点。方法对454例有上消化道症状的小儿胃粘膜活检标本进行组织学观察及病理分型。结果454例病例中，有病理改变者418例（92．07％），主要为淋巴细胞和浆细胞浸润及充血、水肿。病理类型以轻一中度慢性浅表炎为主，占78．4％，胃溃疡及慢性萎缩性胃炎少见。幽门螺杆菌（HP）检出率为37．89％。活动性胃炎HP阳性率为76．32％（P＜0．005）。HP阳性172例病例中，淋巴滤泡检出率为72．67％（P＜0．005）。结论小儿胃粘膜病变以炎症为主，慢性活动性胃炎及淋巴滤泡形成与HP感染关系密切。

To study the immunohistochemical characteristics of mucosa bioptic specimens and analyze the clinico-pathological features in children with upper alimentary canal symptoms.Methods 454 children with upper digestive symptomswere subjected to gastroendoscopy and bioptic speciments were taken for histologic examinations.Results In 4l8 cases(92.07% ), the pathological changes were mainly infiltration of lymphatic cells and palsma cells,hyperemia and edema.Amongthem, chronic superficial gastritis from mild to moderate was predominant(78.4% ), while gastric ulcer and chronic atrophic gas-tritis were less common. The Helicobacter pylori (HP) detected rate was 37. 89% and HP positive rate in active gastritis was76.32% (P < 0.005). Among l72 HP postitive cases, the detective rate of lymphoid follicle was 72.67% (P < 0.005). Con-clusion Gastric mucosa lesions in children tend to be mainly inflammation in that chronic active gastritis and the Presence of lym-phoid follicle are closely related to HP infection.