食管癌与单纯性疱疹病毒的关系

A study of the association between HSV and esophageal carcinoma

目的：观察单纯性疱疹病毒（ＨＳＶ）在食管癌组织中的分布并探讨其与食管癌的关系。方法：对５２ 例食管癌石蜡包埋组织用免疫组化和原位杂交技术进行定位观察。结果：癌组织ＨＳＶ 免疫组化阳性率ＨＳＶ１ 为５３－８ ％ ，ＨＳＶ２ 为５７－７％ ；癌旁食管粘膜ＨＳＶ 为６５－５ ％ ，其中ＨＳＶ１（１２／２９）４１％ ，ＨＳＶ２（１６／２９）５５－２％ 。原位杂交癌阳性率为５３－８ ％ ，癌旁粘膜为５８－６％ 。ＨＳＶ 阳性率与癌组织的分化程度和淋巴结转移相关（ Ｐ＜ ０－０５） ，但与癌组织间质淋巴细胞浸润的强度无关（ Ｐ＞０－０５）。结论：ＨＳＶ感染可能影响食管癌的分化和癌细胞的生物学特性。

Purpose To explore the distribution of herpes simplex virus(HSV) in esophageal carcinoma (EC) and its relationship with the tumor. Methods Fifty two cases of EC were detected by immunohistochemistry and in situ hybridization for HSV infection. Results The positivity rates of HSV 1 and HSV 2 in carcinoma tissue were 53 8% and 57 7% respectively. Positivity rate of HSV infection were related to both the degree of carcinoma differentiation and lymph node matastasis( P<0 05) , and which was not related to the degree of lymphocyte infiltration ( P>0 05) . Conclusion HSV infection may affect the differentiation and the biological features of esophageal cancer.