HPV16、18 E6蛋白在乳腺癌组织中的表达

Expression of human papillomavirus 16、18 E6 protein in breast cancer

目的：观察ＨＰＶ１６ 、１８ Ｅ６ 蛋白在人乳腺癌中的表达并探讨ＨＰＶ１６、１８ 感染与乳腺癌病因学的关系。方法：应用ＳＰ免疫组化法，检测５３ 例乳腺癌、２０ 例正常乳腺组织中ＨＰＶ１６、１８ Ｅ６ 蛋白的表达。结果：乳腺癌组织中ＨＰＶ１６、１８ Ｅ６ 蛋白的阳性表达率为５６－６％ （３０／５３），多种组织学类型的乳腺癌组织中有ＨＰＶ１６、１８ 型感染的存在。结论：ＨＰＶ１６、１８ 型感染可能与乳腺癌的病因学密切相关。

Purpose To observe the expression of human papillomavirus 16、18 E6 protein of human breast cancer and to assess the relationship between HPV 16、18 infection and breast carcinogenesis. Metheds Immunohistochemical S P method was used to detect the expression of HPV 16、18 E6 protein in 53 cases of breast cancer and 20 cases of normal breast tissues. Results The positivity rates of HPV 16、18 E6 were 56 6%(30/53) in the cancer tissues. HPV 16、18 infection was confirmed in some types of breast cancer. Conclussion HPV16、18 infection may play an important role in pathogenesis of human breast cancer.