摘要
目的探讨血浆NT-proBNP(氮端前体脑钠肽)浓度变化在慢性心衰患者中的意义。方法选择慢性心力衰竭患者65例,NYHA分级分为Ⅱ-Ⅳ级,正常对照组21例,测定NT-proBNP血浆浓度。结果各组间NT-proBNP差别有统计学意义(P<0.01),NT-proBNP与NYHA分级呈正相关(r=0.509,P<0.01),抗心衰治疗7天后,与入院时相比各心衰组NT-proBNP明显下降(P<0.01)。结论监测NT-proBNP,对慢性心衰的诊断、严重程度的判断、疗效判定是一项快速简便的指标,值得广泛应用于临床心力衰竭患者。
Objective Study the significance of plasma NT-proBNP changes in patients with chronic heart failure.Methods Select 65 cases with chronic heart failure,divided them intoⅡ-Ⅳclass by NYHA class,21 cases without heart failure were included as the control group.Determine their NT-proBNP plasma concentration.Results The differences of NT-proBNP in different group were significant（P0.01）;NT-proBNP showed positive correlation with NYHA class（r = 0.509,P0.01）;After 7days＇Anti-heart failure therapy,compared to the admission the NT-proBNP in each NYHA class decreased significantly（P0.01）.Conclusion Monitoring NT-proBNP is a quick and easy evaluation on diagnosing accuratly,judging the severity and determing the efficacy of chronic heart failure.It should widely used in clinical heart failure patients.
出处
《疾病监测与控制》
2011年第12期716-718,共3页
Journal of Diseases Monitor and Control
