原发性高血压联合应用厄贝沙坦与硝苯地平对左室肥厚及舒张功能的影响

Hypertension in combination with nifedipine on irbesartan left ventricular hypertrophy and diastolic function

目的:探讨原发性高血压联合应用厄贝沙坦与硝苯地平对左室肥厚及舒张功能的影响,以为临床治疗提供依据。方法:对本院收治的90例原发性高血压患者的临床资料进行回顾性分析,将90例患者随机分为对照组与研究组,每组45例,研究组患者给予厄贝沙坦联合硝苯地平进行治疗,对照组仅给予厄贝沙坦。比较两组患者治疗前后的血压及心功能指标的变化情况。结果:患者治疗后SBP研究组为(140.3±6.1)mmHg,对照组为(138.5±7.2)mmHg;DBP研究组为(81.2±0.9)mmHg,对照组为(82.1±0.3)mmHg;两组患者治疗前后血压变化差异有统计学意义,P<0.05;研究组与对照组比较,差异无统计学意义,P>0.05。两组患者治疗前后心功能指标均有所改善,研究组患者的心功能改善情况明好于对照组,两组间比较,P<0.05。结论:厄贝沙坦与硝苯地平联合应用能够更好地改善原发性高血压患者的左室肥厚及舒张功能,值得临床进一步研究应用。

Objective：To evaluate the combination of irbesartan and hypertension nifedipine on left ventricular hypertrophy and diastolic function,that provide the basis for clinical treatment.Methods：90 patients with essential hypertension clinical data were retrospectively analyzed and were randomly divided into control group and study groups of 45 cases,the study group were treated with irbesartan nitrate benzene horizon for treatment,the control group were given irbesartan.Two groups were compared before and after treatment of blood pressure and cardiac function changes.Results：After treatment,SBP in study group was（140.3±6.1） mmHg,in control group was（138.5±7.2） mmHg;DBP in study group was（81.2±0.9） mmHg,in control group was（82.1±0.3） mmHg,difference of two group patients changes in blood pressure before and after treatment was statistically significant,P〈0.05;difference of the study group and control group was not statistically significant,P〈0.05.Two groups of patients before and after treatment had improved cardiac function,and the study group was better than the control group,P〈0.05.Conclusion：The combination of irbesartan and nifedipine are better able to improve left ventricular hypertrophy in patients with essential hypertension and diastolic function,is worthy of further research applications.