盐酸氨溴索和盐酸溴己新在慢性阻塞性肺疾病急性加重期治疗中的临床疗效比较

Clinical investigation of ambroxol and bromhexine hydrochloride in treating acute exacerbation of chronic obstructive pulmonary disease

目的:探讨盐酸氨溴索和盐酸溴己新在慢性阻塞性肺疾病急性加重期治疗中的临床应用价值。方法:本院呼吸科收治的60例确诊的COPD加重期患者,分为治疗组和对照组各30例。两组均给予相同对症支持治疗的基础上,对照组口服盐酸溴己新祛痰16mg,3次/d,10d;治疗组静脉注射盐酸氨溴索30mg,2次/d,10d。记录两组治疗后有效率,治疗前后两组的呼吸频率、氧饱和度等指标。结果:治疗前两组的呼吸频率和氧饱和度差异无统计学意义(P>0.05),治疗后治疗组的氧饱和度为(98.1±2.2)%,显著高于对照组的(89.1±2.5)%(t=5.899,P<0.05);治疗组呼吸频率显著低于对照组(t=5.211,P<0.05);治疗组总有效率(100.0%)显著高于对照组(90.0%)(χ2=5.001,P<0.05)。结论:盐酸氨溴索治疗慢性阻塞性肺疾病加重期疗效较盐酸溴己新优,值得临床推广。

Objective：To investigate the clinical significance of ambroxol and bromhexine hydrochloride in treating acute exacerbation of chronic obstructive pulmonary disease（COPD）.Methods：A total of 60 patients with acute exacerbation of COPD,of which 30 cases were submitted to bromhexine hydrochloride and 30 were treated by Ambroxol and Saline,were enrolled in the study.Both groups were all given the same support treatment,and on the basis of oral hydrochloric acid in the control group had bromhexine hydrochloride 16 mg,3 times one day,10 d;The treatment group mainlined ambroxol 30 mg,2 times one day,10 d.The efficacy,respiratory rate,oxygen saturation of before and after treatment were analyzed.Results：In post-therapy,the oxygen saturation of treatment group was higher than the control group（t=5.899,P0.05）;respiratory rate of treatment group was lower than the control group（t=5.211,P0.05）;the total effective rate of treatment group was higher than the control group（χ2=5.001,P0.05）.Conclusion：Ambroxol has better efficacy compared with bromhexine hydrochloride in treating acute exacerbation of COPD,which deserves being populated.