体重指数对轻度持续性哮喘儿童吸入布地奈德的疗效影响

Efficacy of body mass index on inhaled budesonide for treatment of children with mild persistent asthma

目的:进一步探讨了解体重指数对轻度持续性哮喘儿童吸入布地奈德治疗效果的影响。方法:选取本院儿科在2009年1月～2011年1月收治的66例轻度持续性哮喘儿童患者,将所有患儿随机分为3组,正常体重者一组、超重者一组、肥胖者一组,均给予患儿布地奈德吸入治疗,观察所有患儿的肺功能FEV1的差异。结果:3组哮喘患儿在治疗前后其FEV1指标比较,差异有统计学意义(P<0.05),治疗后较治疗前FEV1明显增加。肥胖组患儿FEV1增加量和正常体重患儿的增加值比较,差异有统计学意义(P<0.05),前者的增加值小于后者的增加值。结论:肥胖因素可能影响布地奈德的治疗效果。

Objective： To further explore the effects of body mass index on inhaled budesonide for the treatment of children with mild persistent asthma. Methods： 66 children with mild persistent asthma admitted and treated in the department of pediatrics of our hospital from January 2009 to January 2011 were randomly divided into three groups, namely a group of normal children, a group of overweight children and a group of obese children. All the children were given budesonide inhalation therapy and then the differences of lung function forced expiratory volume in 1 second （FEV1） between the three groups of children were observed. Results： The FEV1 indicators of the three groups of children before and after treatment showed statistical differences （P0.05）. FEV1 increased significantly after treatment compared with those before treatment. The FEV1 increase of the group of obese children was statistically different from that of the group of normal children （P 0.05）, with the former increase lower than the latter one. Conclusion： Obesity may affect the treatment efficacy of budesonide.