异位妊娠甲氨蝶呤治疗后血β-HCG变化临床分析

Analysis of β-HCG change of MTX chemotherapy on ectopic pregnancy

目的:探讨异位妊娠患者甲氨蝶呤(MTX)化疗后血β-HCG变化特点。方法:回顾分析2008年1月～2009年12月甲氨蝶呤治疗异位妊娠患者40例。将治疗期间血β-HCG值变化分别绘制成曲线图,并按图形不同特点分为3组,即失败组、下降组和折线组。统计患者年龄、停经天数、血β-HCG值、入院期间B超所示附件区包块的最大径线、血β-HCG峰值与峰值前谷值比率、治疗总天数等。结果:失败组与折线组血β-HCG峰值与峰值前谷值比率差异有统计学意义(P<0.05);折线组治疗总天数明显多于下降组,差异有统计学意义(P<0.05)。结论:血β–HCG变化特点,对甲氨蝶呤治疗异位妊娠的疗效判定、治疗方案调整、用药指导等有指导意义。

Objective： To discuss blood β-HCG change characteristic of ectopic pregnancy patient after MTX treatment. Methods： Retrospectively analyzed the conservative treatment of ectopic pregnancy with methotrexate in 40 patients from January 2008 to December 2009. Serum β-HCG values during treatment were plotted into curves and were divided into 3 groups according to the pattern characteristics, namely failure group, descent group and broken line group. Each group was analyzed in its patient age, menopausal days, serum beta -HCG value, maximum diameter of adnexal mass, serum betaHCG peak and peak valley ratio, the total treatment days etc. Results： β-HCG ratio of peak to valley of failure group and broken line group was significantly different （P0.05）; The total treatment days of broken line group were more than the descent group, there were significant differences （P0.05）. Conclusion： The various tendency of the serum β-HCG curve has important significance in MTX treatment for ectopic pregnancy, such as curative effect judgment, treatment plan adjustment, medication guide, and so on.