^(14)C呼气试验与快速尿素酶试验检测幽门螺杆菌感染的对比研究

Comparation of the difference of diagnostic value between 14 C -urea breath test and rapid urease test for helicobacter pylori Infection

目的:探讨14C呼气试验和快速尿素酶试验两种方法对幽门螺杆菌(H.pylori)感染的诊断价值。方法:107例有消化道症状的患者,分别用14C呼气试验和快速尿素酶试验两种方法进行检测,比较两种方法对H.pylori检测符合率及灵敏度、特异度、阳性预测值和阴性预测值。结果:两种方法对H.pylori感染的检出率分别为92.0%和89.8%,但差异无统计学意义。14C呼气试验的灵敏度、特异度、阳性预测值和阴性预测值分别为92.7%、88.0%、93.8%和84.6%。快速尿素酶试验灵敏度、特异度、阳性预测值和阴性预测值分别为87.8%、80.0%、91.1%和71.4%。结论:14C呼气试验和快速尿素酶试验对H.pylori感染的诊断均有很高的敏感性和特异性,是临床上用于H.pylori感染诊断的可靠方法。

Objective： To compare the difference of diagnosis value between 14 C-urea breath test and rapid urease test in detecting helicobacter pylori. Methods： A sample of 107 outpatients with digestive tractsymptom were screened for helicobacter pylori infection with 14 C-urea breath test （UBT）, rapid urease test （RUT） on fresh biopsy. Direct smear method was used as gold standard. Sensitivity, specificity, positive and negative predictive values were calculated and compared. Results： The detectable rates of H.pylori were 92.0% and 89.8% tested by two methods, there were usually no significant difference. Sensitivities, specificities, positive predictive value and negative predictive value were 92.7%, 88.0%, 93.8% and 84.6% respectively, for the 14 C-urea breath test; Sensitivities, specificities, positive predictive value and negative predictive value were 87.8%, 80.0%, 91.1% and 71.4%, respectively, for rapid urease test. Conclusion： Both 14 C-urea breath test and rapid urease test show a high accuracy to detect the helicobacter pylori infection. They are dependable methods for clinical in detecting helicobacter pylori.