巨幼细胞性贫血细胞形态学诊断分析

Diagnosis on the megaloblastic anemia of cell morphocytology

目的:通过对巨幼细胞性贫血(MA)细胞形态学的分析以明确MA的临床诊断。方法:对本院血液科2009年6月～2011年6月收治的60例MA患者的临床病例资料进行回顾性分析。结果:血常规中全血细胞减少者32例,5例以粒系细胞显著增生和巨幼变为特征,9例以红系细胞显著增生和巨幼变为特征,其余46例以红系细胞和粒系细胞显著增生和巨幼变为特征。结论:临床上通过对MA患者从血常规、骨髓象进行细胞形态学的分析,结合其临床表现可对其进行有效诊断,并可与再生障碍性贫血、骨髓异常增生综合征及溶血性贫血进行有效鉴别。在治疗上,及时有效补充叶酸或维生素B12可明显改善MA患者的症状。

Objective： To figure out the morphological characteristics of megaloblastic anemia （MA） with cell morphological analysis, and then to help the accurate diagnosis in clinics. Methods： Retrospective analyzed the clinical material of 60 cases of megaloblastic anemia patients who were from our courtyard admits from June 2009 to June 2011. Results： For routine blood test, there were 32 patients that hemocyte was reduced, 5 patients that myeloid cells were obviously proliferated and megaloblastic changed, 9 patients that erythroid cells were obviously proliferated and megaloblastic changed, the rest of 46 patients were obviously proliferated and megaloblastic changed both of myeloid cells and erythroid cells. Conclusion： Megaloblastic anemia could be effectively diagnosised though the analysis of blood relative and bone marrow relative combined with clinical manifestation. And to differentiate among aplastic anemia ,myelodysplastic syndromeand and hemolytic anemia. Timely and effective Folic acid and Vitamin B 12 supplement could obviously improve the symptom for treatment of megaloblastic anemia patients.