哮喘患者血清中IL-4、IL-18和IgE水平的变化和意义被引量：7

Alteration and Significance of IL-4,IL-18 and IgE in Bronchial Asthma

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摘要目的探讨血清中IL-4、IL-18和IgE水平变化在哮喘患者中的意义。方法选取2009年12月至2010年12月来我院呼吸内科诊治的支气管哮喘患者30例及同期在院体检的健康者20例为对照,采用酶联免疫吸附实验法(ELISA)检测患者及对照组血清中IL-4、IL-18和IgE水平。结果 IL-4、IL-18和IgE水平在哮喘患者比对照组明显升高,差异有统计学意义(P<0.05)。并且在哮喘患者中,急性发作组三者的水平较缓解组也升高,差异有统计学意义(P<0.05)。结论血清中IL-4、IL-18和IgE水平增加与支气管哮喘发病密切相关。 Objective To evaluate the alteration and significance of serum IL-4,IL-18 and IgE in bronchial asthma.Methods Blood samples of 30 bronchial asthma and 20 healthy individuals as control group were collected.Samples of serum IL-4,IL-18 and IgE concentration were analyzed by enzymelinked immunosorbent assay（ELISA）,followed by comparisons of IL-4,IL-18 and IgE levels among all groups.Result The levels of IL-4,IL-18 and IgE in bronchial asthma patients were significantly higher than that of normal control group（P〈0.05）.And the level of acute episode group was higher than that of paracmasia group in bronchial asthma patients（P〈0.05）.Conclusion Augmentation of serum IL-4,IL-18 and IgE had close correlation with bronchial asthma.

作者高小燕卢慧宇

机构地区南通大学附属泰州人民医院呼吸内科

出处《中国医药指南》 2011年第33期22-23,共2页 Guide of China Medicine

关键词哮喘 IL-4 IL-18 IGE Bronchial asthma IL-4 IL-18 IgE

分类号 R562.25 [医药卫生—呼吸系统]

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