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盐酸安非他酮与盐酸氟西汀治疗抑郁症的临床研究 被引量：2

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摘要 目的比较安非他酮与氟西汀对抑郁症的疗效和安全性。方法将125例抑郁症患者随机分为两组,研究组口服安非他酮治疗,对照组口服氟西汀治疗,均6周一个疗程。研究组63例,男30例,女33例;平均年龄(38.8±12.4)岁,平均病程(15.5±4.9)个月,予安非他酮300～450mg/d,po,tid。对照组62例,男28例,女34例;平均年龄(35.9±11.1)岁,平均病程(14.9±8.6)个月,予氟西汀20～40mg/d,po,qd。结果对抑郁症的治疗,安非他酮组显效率71%,氟西汀组为74%,两组间疗效比较无显著性差异(P>0.05);对伴随焦虑症状的治疗,安非他酮组显效率48%,氟西汀组显效率45%,两组比较无显著性差异(P>0.05)。两组不良反应发生率均较低,且程度较轻微。结论安非他酮与帕罗西汀治疗抑郁症总体疗效相当,能有效治疗抑郁及伴随焦虑症状,且安全性高。
作者 徐国洪 黄少平
机构地区 佛山市第三人民医院
出处 《中国医药指南》 2011年第33期120-121,共2页 Guide of China Medicine
关键词 抗抑郁药 安非他酮 抑郁症 氟西汀
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献9

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二级参考文献18

  • 1Tomarken AJ, Dichter GS, Freid C, et.al. Assessing the effects of bupropion SR on mood dimensions of depression. J Affect Disord, 2004, 78(3): 235-241.
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  • 10TOMARKEN AJ, DICHTER GS, FREID C, et al. Assessing the effects of bupropion SR on mood dimensions of depression [J]. JAffect Disord, 2004, 78(3): 235-241.

共引文献18

同被引文献34

引证文献2

二级引证文献20

中国医药指南
2011年 第33期

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