奥拉西坦治疗糖尿病性眼肌麻痹的临床观察

The Clinical Observation of Oxiracetam Treatment of Diabetic Ophthalmoplegia

目的观察奥拉西坦注射液治糖尿病性肌麻痹疗糖尿病性肌麻痹的临床疗效。方法 52例患者随机分成治疗组和对照组,对照组给予弥可保注射液500mg肌内注射,每天1次,同时给予维生素B1、三磷酸腺二苷、肌苷、复方血栓通胶囊等药物口服;治疗组是在对照组的基础上应用奥拉西坦注射液3g加入0.9%生理盐水250mL静脉滴注。结果治疗组有效率88.4%,对照组有效率65.3%,治疗组和对照组两组间差异有统计学意义(P<0.05)。结论奥拉西坦注射液对糖尿病性眼肌麻痹病变有显著的治疗作用,有较高的临床应用价值。

Objective This study was to observe the effects of Oxiracetam curing diabetogenous ophthalmoplegia.Methods Fifty-two diabetogenous ophthalmoplegia patients were divided into 2 groups randomLy,including treat group（n=26） and control group（n=26）.Control group was given 500mg intramuscular of Mecobalamin once a day,at the same time,Vitamin B1,ATP,inosine and Compound thrombus capsule were necessary.Treat group was applied to 250mL still drop mixed with 3g Oxiracetam injection and physiological saline of 0.9%.Both were made two courses of treatment about twenty days in total,then compared.Results The effective power of treat group was 88.4%,the other was 65.3%.The difference of these two groups had statistical significance（P〈0.05）.During the following up of clinical application drugs,there was no side effect found.Conclusion Oxiracetam had markedly curing effect on diabetogenous ophthalmoplegia,which was worth extending on clinical.