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食管癌患者血清胸苷激酶1检测的外科临床意义 被引量：3

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摘要 目的探讨血清胸苷激酶1(thymidine kinase 1,TK1)检测对食管癌辅助诊断及术后效果评估的意义。方法应用免疫印迹—增强化学发光法(ECL)检测348例食管癌手术患者术前、术后1周以及手术1～3个月的血清TK1水平,另外加入41例健康体检者作为对照组,检测其血清TK1水平,并对部分术后患者随访12个月。结果食管癌患者血清TK1水平明显高于健康对照组(P<0.05);癌患者手术后1周,血清TK1水平明显上升(P<0.05),而在术后1～3个月回落,并明显低于术前水平(P<0.05);完成对45例患者12个月随访,发现术后1～3个月TK1水平上升患者复发比例远远大于下降组(P<0.001)。结论血清TK1水平反映细胞增殖,连续跟踪结果有利于对食管癌手术治疗效果的辅助诊断,对临床监视肿瘤手术疗效,判断复发风险具有临床意义。
作者 赵国红 柳硕岩 杨永 Ellen He Sven Skog
机构地区 福建省肿瘤医院胸外科 Department of Oncology
出处 《中国医药指南》 2011年第33期305-307,共3页 Guide of China Medicine
关键词 食管癌 胸苷激酶1 检测
分类号 R735.1 [医药卫生—肿瘤]
  • 相关文献

参考文献14

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二级参考文献31

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共引文献30

同被引文献46

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二级引证文献13

中国医药指南
2011年 第33期

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