代谢综合征对老年糖尿病患者动脉僵硬度的影响

Impact of metabolic syndrome on arterial stiffness in elderly type 2 diabetic patients

目的探讨老年糖尿病患者合并代谢综合征(MS)动脉僵硬度的变化及影响因素。方法选择老年糖尿病患者305例,根据是否合并MS分为MS组143例、非MS组162例;另选老年葡萄糖耐量试验正常者65例为对照组。检测颈-股脉搏波传导速度(PWV)、体重指数、腰围、血压、高敏C反应蛋白、血脂、空腹血糖、胰岛素及胰岛素抵抗指数,进行比较分析。结果 MS组和非MS组患者PWV明显高于对照组(P<0.05);随着MS组分增加,PWV呈阶梯样增加(P<0.05)。多元回归分析显示,PWV与年龄、血压、MS组分、高敏C反应蛋白、胰岛素抵抗指数及空腹血糖呈正相关(P<0.05)。结论老年糖尿病患者动脉僵硬度明显增加,合并MS加重动脉僵硬。

Objective To investigate the impact of metabolic syndrome（MS） on arterial stiffness in elderly type 2 diabetes mellitus patients（T2DM）. Method According to MS criteria,305 cases of elderly DM patients were divided into MS group and non- MS group. Meanwhile,65 cases of NGT elderly were selected as control group carotid-femoral pulse wave velocity（PWV）, body mass in- dex（BMl）, waist circumstance, blood pressure, blood glucose, blood lipid, insulin, homeostasis model assessment of insulin resistance （HOMA-IR） and high-sensitive C-reaction proetin （hs-CRP） were measured in all subjects. Results From control group, non-MS group to MS group,PWV increased significantly（P〈0.05） ; furthermore,with components of MS increasing, PWV was increased gradually. Multiple regression analysis show PWV are positively correlated with age,blood pressure,the number ot7 MS components, hs-CRP, HOMA-IR and fasting blood glucose（P%0.05）. Conclusion MS increases arterial stiffness in elderly T2DM patients.