老年人群代谢异常与认知功能的相关性研究

Relationship between metabolic abnormality and cognitive function

目的对老年人群进行认知功能评定,探讨代谢异常因素对认知功能的影响,为老年痴呆的早防、早治提供依据。方法选择老年人群2315例,根据简易智能状态检查量表(MMSE),分为MMSE正常组(2283例)和MMSE异常组(32例),进行流行病学调查,检测身高、体重、腰臀围、血压、血脂、血糖等指标,并进行统计学分析。结果 MMSE异常组年龄、腰围、腰臀比、HDL-C、收缩压、空腹血糖明显高于MMSE正常组,差异有统计学意义(P<0.05)。中心性肥胖、超重或肥胖、HDL-C异常、高血压、空腹血糖升高人群MMSE评分明显低于对应正常人群,差异有统计学意义(P<0.05,P<0.01)。Pearson相关分析显示,体重指数、腰围、腰臀比、收缩压、空腹血糖与MMSE评分呈负相关,HDL-C与MMSE评分呈正相关。线性多元回归分析显示,MMSE评分与受教育程度、经济收入、吸烟、饮酒、年龄、腰围、收缩压、空腹血糖和HDL-C密切相关。结论老年人群的认知功能与年龄、受教育程度、吸烟及饮酒等密切相关,同时中心性肥胖、高血压、血脂异常及高血糖等代谢异常与认知功能障碍的受损程度亦密切相关。

Objective To evaluate the cognition of senile residents and to examine the association of metabolic risk factors with cognitive function. Method We performed a cross-sectional study in a population of 2315. Global cognitive function was measured by the mini-mental state examination （MMSE）. The subjects were seperated into MMSE normal group（2283） and abnormal group （32）. All subjects answered questionnaire and received physical and biochemical examination. Results The levels of age,waistline, ratio of waist to hip, fasting plasma glucose（FPG）, systolic blood pressure（SBP）,and HDL-C in the MMSE abnormal group were higher than those in the MMSE normal group（P〈0.05）. In the group with central obesity,overweight or obesity,abnormal HDL-C, hypertension or impaired FPG,MMSE score was significantly lower than that in the control group（P〈0.05, P〈0.01）. Pearson correlation analysis showed that body mass index, waistline, ratio of waist to hip, SBP and FPG were negatively related with MMSE score, while HDL-C was positively related with it. Linear regression test showed that MMSE score was related with age, education, income, smoking, alcohol drinking, waistline, SBP, HDL-C and FPG. Conclusions For senile residents,metabolic risk factors may be the important contributors to cognitive impairment except age, education, income, smoking and alcohol drinking.