中兽药复方“连藤”的抗炎作用及安全性评价

Anti-inflammatory Effect and Safety Evaluation of a Chinese Traditional Veterinary Compound Preparation "Lianteng"

试验选择中草药连翘、青风藤等配伍组成复方制剂"连藤",采用水煎醇提法提取该复方制剂有效成分,通过急性毒性试验、最大耐受量试验、异常毒性试验对复方"连藤"的安全性进行评价,经二甲苯致小鼠耳廓肿胀试验检测复方"连藤"的抗炎作用。结果表明,复方"连藤"为实际无毒,其最大耐受量为18g/(kg·bw);在体内抗炎试验中,复方"连藤"的高[10.0g/(kg·bw)]、中[5.0g/(kg·bw)]剂量组的肿胀抑制作用明显高于阳性对照(地塞米松)组。复方"连藤"安全、无毒且有良好的抗炎作用,具有开发潜力。

The compound preparation ＂Lianteng＂ was composed of Chinese herbal medicine Forsythia suspensa （Thunb.）Vahl and Caulis sinomenii. The effective components of this compound preparation were extracted by using water decoction and ethanol extraction method. By acute toxicity test, maximum tolerance test and abnormal toxicity test, the safety of the compound preparation ＂Lianteng＂ was evaluated. The anti-inflammatory function of the compound preparation ＂Lianteng＂ was detected by using dimethylbenzene-induced auricle-swollen test of mice. The results showed that the compound preparation ＂Lianteng＂ was nontoxic and the maximum tolerance dose was 18 g/（kg.bw）. In the anti-inflammatory test in vivo, the repression rate of swelling in high dose group [ 10.0 g/（kg.bw） ] and medium dose group [5.0 g/（kg.bw） ] of compound preparation ＂Lianteng＂ was obviously higher than that in positive control group （dexamethasone） . The compound preparation ＂Lianteng＂ was safe and nontoxic and it had good anti-inflammatory effects and developmental potential .