米非司酮联合甲氨蝶呤保守治疗异位妊娠的疗效观察

Efficacy Observation of Mifepristone Combined with Methotrexate Conservative Treatment for Ectopic Pregnancy

目的:观察米非司酮联合甲氨蝶呤(MTX)保守治疗异位妊娠的效果。方法:选择我院异位妊娠患者243例,按随机数字表法将入组患者分为米非司酮+MTX组(122例)和米非司酮组(121例)。观察并记录住院时间、阴道流血时间、β-绒毛膜促性腺激素(β-HCG)下降至正常时间、包块缩小时间、腹痛例数、转手术例数、造影通畅例数,了解治疗的安全性和有效性。结果:米非司酮+MTX组阴道流血时间、β-HCG下降至正常的时间、包块缩小的时间、腹痛的例数均显著优于米非司酮组(P<0.05),2组在出现副反应及输卵管通畅程度的比较上差异无统计学意义(P>0.05)。结论:米非司酮+MTX治疗异位妊娠疗效较好,安全性高。

To observe the therapeutic efficacy of mifepristone combined with methotrexate in the treatment of ec- topic pregnancy. METHODS： 243 patients with ectopic pregnancy in our hospital were randomly divided into mifepristone group （121 cases） and mifepristone combined with methotrexate group（122 cases） according to random number table. The length of stay, vaginal bleeding time, the time of fl-HCG dropping to normal, the time of mass reduction, abdominal pain, transfer surgery and case number of smooth radiography were observed and recorded. RESULTS ： The vaginal bleeding time, the time of fl-HCG dropping to normal, the time of mass reduction, case number of abdominal pain in mifepristone combined with methotrexate group were signifi- cantly better than mifepristone group （P〈0.05）. There was no statistical significance in adverse drug reaction and the degree of tubal patency between 2 groups （P〉0.05）. CONCLUSION： Mifepriston combined with methotrexte in the treatment of ectopic pregnancy has mood efficacy and low ADRs.