65例育龄期妇女垂体泌乳素微腺瘤治疗分析

Treatment and analysis on 65 women of childbearing age with pituitary microprolactinoma

目的:探讨经鼻蝶窦入路显微手术及溴隐亭药物治疗育龄期妇女垂体泌乳素微腺瘤的临床治疗效果。方法:研究2007年4月-2010年11月收治的65例育龄期女性垂体泌乳素微腺瘤患者,经鼻蝶显微手术40例,药物(溴隐亭)保守治疗25例,对手术治疗和药物治疗后患者月经恢复情况、血PRL变化及生育情况进行统计学分析。结果:手术治疗和药物治疗后月经恢复情况、血PRL变化差异无统计学意义(P>0.05);手术治疗和药物治疗后生育情况差异有统计学意义(P<0.05),手术组优于药物治疗组。结论:在育龄期女性垂体泌乳素微腺瘤的治疗上,经鼻蝶显微手术治疗优于药物(溴隐亭)保守治疗,但在实际治疗方案选择上应根据患者具体情况进行个性化治疗。

Objective：To explore the clinical curative effect of nasal transsphenoidal microsurgery and bromocriptine in treatment of pituitary microprolactinoma among the women of childbearing age.Methods：65 women of childbearing age with pituitary microprolactinoma who were treated in the hospital from April 2007 to November 2010 were selected,40 women were treated with nasal transsphenoidal microsurgery and 25 women were treated with bromocriptine,the recoveries of menstruation after treatment,the changes of blood prolactin levels and reproductive conditions in the two groups were analyzed statistically.Results：There was no significant difference in recovery of menstruation after treatment and the change of blood prolactin level between the two groups（P0.05）;but there was significant difference in reproductive condition between the two groups（P0.05）,surgery group was superior to drug treatment group.Conclusion：The curative effect of nasal transsphenoidal microsurgery is superior to that of bromocriptine in treatment of the women of childbearing age with pituitary microprolactinoma,but referring to choice of actual therapeutic schedule,individualized treatment should be taken according to the specific circumstances of the patients.