癫痫发作后神经元凋亡的多重调控机制

Multiple regulatory mechanisms of neuronal apoptosis after seizures

癫痫是一种慢性脑部疾病。以脑部神经元过度同步化放电所致的突然、反复和短暂的中枢神经系统功能失常为特征。细胞凋亡(apoptosis)是由基因控制的由细胞内部程序激活而发生的自杀性死亡,它在细胞分化、促进体内正常细胞的更新和调节机体发育等方面都起到重要作用。细胞凋亡是癫痫发作后神经元丢失的重要形式。目前认为,癫痫发作后细胞凋亡分子水平的多重调控主要集中在三个方面:(1)细胞凋亡的相关基因及其调控方面;(2)caspase(cysteine proteinases with specificity for aspartic acidresidues,半胱天冬氨酸酶)在细胞凋亡中的作用;(3)线粒体途径在细胞凋亡中的作用。

Epilepsy is a chronic brain disease long-term, recurrent and refractory characteristics, it is caused by excessive discharge in the neurons of brain with sudden, repeated and temporary dysfunction of the central nervous system characteristics. Apoptosis is a physiological mode of cell death under conditions which regulate the development of body, cell differentiation and normal cell re- newal in vivo. Apoptosis is an important form of neuronal loss a^er the seizure. There are three mainly aspects of apoptosis of multiple control the molecular level after seizures at the present： （1）Apoptosis-related genes and their regulatory aspects; （2） caspase （cysteine proteinases with specificity for aspartic acid residues）; （3）The role ofmitochondrial pathway in apoptosis.