热性惊厥患儿T淋巴细胞和红细胞免疫功能的实验研究

The changes of immune function of T lymphocyte and erythrocyte in children with febrile convulsion

目的 探讨小儿热性惊厥的Ｔ 淋巴细胞和红细胞免疫功能变化。方法 对７２ 例热性惊厥患儿及３５ 例健康儿童应用微量全血氚标记胸腺嘧啶核苷（３Ｈ —Ｔｄ Ｒ） 掺入法作Ｔ 细胞增殖实验，用酵母花环实验测红细胞免疫粘附功能。结果 热性惊厥患儿外周血Ｔ 细胞增殖反应水平明显降低，以复杂性热性惊厥患儿尤为明显，ＣＰＭ 和ＳＩ 均显著低于健康对照组（ Ｐ＜ ０ ．００１） ； 热性惊厥患儿红细胞Ｃ３ｂ 受体花形成率（ ＲＢＣ －Ｃ３ｂＲＲ） 明显较健康组为低（ Ｐ＜ ０ ．０５） ，但红细胞免疫复合物花环形成率（ ＲＢＣ—ＩＣＲ） 则无明显差异。结论 提示热性惊厥患儿在惊厥发作时存在Ｔ 淋巴细胞和红细胞免疫功能低下。

Objective\ To study the changes of immune function of T ymphocyte and erythrocyte in children with febrile convulsion.Methods\ T lymphocyte proliferation was determined by micro-whole-blood H-thymidine assay and erythrocyte immune adhesion function were determined by RBC-C\-3bRR and RBC-ICR tests.Results\ The peripheral blood T (ymphocyte proliferation level in febrile convulsion subjects were significantly decreased that C P M and SI were all significantly less than those of the healthy control subjects (P<0.001).It were obvious that the decreased level was very more significant in the complex febrile convulsion subjects.The RBC-C\-3bRR of children with febrile convulsion were significantly lower than that of the healthy control subjects but RBC-ICR were of no significant difference between the febrile convulsion subjects and the helthy subjects.Conclusion\ It suggested that the immune function of both the T lymphocyte and erythrocyte in children with febrile convulsion were simultaneously lowered during convulsion.