20例新生儿肺动脉高压的临床分析

Clinical analysis for twenty neonates with persistent pulmonary hypertension

新生儿肺动脉高压症20例,均由超声心动图证实。其中原发性肺动脉高压3例;继发性肺动脉高压17例,12例继发于先天性心脏病,5例继发于围产期窒息、吸入性肺炎及湿肺。4例无先天性心脏病的患儿用硫酸镁(MgSO_4)治疗,临床有效。治疗后动脉血氧饱和度(SaO_2)和动脉化毛细血管法测定氧分压(PaO_2)明显升高,二氧化碳分压(PaCO_2)降低,吸入氧浓度(FiO_2)减少,没有发现明显的药物副作用。本组死亡6例(30％),14例存活者中2例自愈,1例手术治愈,6例药物治愈,2例仍存在肺动脉高压,3例失随访。

Persistent pulmonary hypertension (PPH) were diagnosed by ultrasono cardiography in 20 newborn infants in whom there were three primary and 17 secondary PPH. PPH was caused in 12 cases by congenital heart disease and in 5 cases by perinatal asphyxia, aspiration pneumonia and wet lung, respectively. Four PPH cases with congenital heart disease received magnesium sulphate (MgSO4) effectively. The arterial blood oxygen saturation (SaO2) and arterial partial pressure (PaO2) determined by capillary method increased and partial pressure of carbon dioxide (PaCO2) decreased significantly after treatment. The amounts of supplemental oxygen (FiO2) were also found to reduce obviously. No any side effects were found on MgSO4. 6 neonates were earlily dead, amony whom the recovery with medical management was got in 6 cases,the recovery via operation in 2 cases, spontaneous recovery in 2 cases, the existence of PPH in cases and missing follow-up in 3 cases.