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氧化应激在糖尿病视网膜病变中的作用

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摘要 高血糖是糖尿病视网膜病变的基础，该病一般认为是由于视网膜微血管系统受损所致。研究表明，AGEs或ROS可抑制视网膜周细胞内PEDFmRNA的表达，造成PEDF水平下降，而PEDF水平下降可使氧化应激诱导的周细胞凋亡及功能障碍进一步加剧，从而促进DR的发展。氧化应激作为DR发病机制之一．使用合适的抗氧化剂可能改善DR患者视网膜组织的代谢和功能异常．延缓DR发展。
作者 戴如春 张玲 吴博
机构地区 中南大学湘雅二医院代谢内分泌研究所
出处 《药品评价》 CAS 2011年第19期18-21,共4页 Drug Evaluation
关键词 糖尿病视网膜病变 氧化应激 氨基己糖途径 多元醇代谢异常
分类号 R587.2 [医药卫生—内分泌]
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参考文献18

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2011年 第19期

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