亚叶酸钙、氟尿嘧啶、顺铂方案治疗晚期胃肠道腺癌42例的效果观察

OBSERVATION OF THE CLINICAL EFFECTS OF ADVANCED PRIMARY G Ⅰ ADENOCARCINOMA TREATED BY CF/5 FU,DDP REGIMEN

目的 观察亚叶酸钙（ＣＦ） 、氟尿嘧啶（５ＦＵ）、顺铂（ＤＤＰ） 方案治疗晚期胃肠道腺癌的效果。 方法 应用ＣＦ、５ＦＵ、ＤＤＰ方案治疗胃腺癌２８ 例和结直肠腺癌１４ 例。ＣＦ每天２００ ｍｇ次或１００ ｍｇ次，静脉滴注，连用５ 天；５ＦＵ每天１０００ ｍｇ次，静脉滴注，连用５ 天，或每天５００ ｍｇ次，连用１０ 天；ＤＤＰ每天２０ ｍｇ次，静脉滴注连用５ 天，或每天６０ ～８０ ｍｇ次，连用２ 天，休息到第２１ 天重复用药后为一个疗程。 结果 治疗胃腺癌２８ 例（有３ 例治疗２ 个疗程）中，完全缓解（ＣＲ）２ 例，部分缓解（ＰＲ）１２ 例，总缓解率为５０％ ；结直肠腺癌１４ 例（有２ 例治疗２ 个疗程）ＣＲ１例，ＰＲ３ 例，总缓解率２８－５％ 。不良反应主要为消化道反应、血象下降和肾功能损伤。 结论 本方案较ＣＦ、５ＦＵ方案疗效高。

PURPOSE 42 patients with primary gastric and colorectal adenocancinoma were treated with CF/5 FU,DDP regimen METHODS CF was admnistered in a dose of 200 mg/d or 100 mg/d on days 1 to 5,Intravenously(IV),1000 mg/d of 5 FU were given IV,continuously for five days,or 500 mg/day of 5 FU were given IV for 10 days,20 mg/day of DDP were given IV for 5 days,or 60～80 mg/d for 2 days.The above was repeated every 3 weeks.RESULTS Of 28 gastric adenocarcinomas(3 cases were treated for two courses)achieved 2 CR 12 PR the response rate(CR+PR) was 50%;of 14 colorectal carcinomas(2 cases were treated for two courses)1 CR, 3 PR,CR+PR 28.5%.Main toxic side effects included anorexia,nausea vomiting,leucopenia and impairment of renal function.CONCLUSIONS The results suggested that there were slightly higher response rates with the CF/5 FU、DDP than CF/5 FU only,but the side reactions are serious.