丁丙诺啡用于癌症病人术后镇痛疗效观察

INTRAMUSCULAR BUPRENORPHINE INJECTION FOR POSTOPERATIVE ANALGESIA OF CANCER PATIENT

目的 研究丁丙诺啡治疗癌症患者术后疼痛的价值。 方法 选择术后患者４０ 例，随机分成两组，组Ⅰ肌内注射丁丙诺啡０－３ｍｇ，组Ⅱ肌肉注射丁丙诺啡０－１５ ｍｇ，观察两组的镇痛起效时间、持续时间及副作用。 结果 丁丙诺啡肌内注射能明显减轻患者疼痛，镇痛效果组Ⅰ明显优于组Ⅱ，组Ⅰ和组Ⅱ的镇痛持续时间分别为９－４７ ±４－４９ｈ 和４－９５±３－８７ｈ（ｔ＝３－５３ ，Ｐ＜０－０１） 。同时测得组Ⅰ患者在肌内注射丁丙诺啡前后的心率、血压、血氧饱和度、呼吸频率、潮气量无明显变化（Ｐ＞０－０５） 。 结论 ０－３ ｍｇ 的丁丙诺啡肌内注射有镇痛效果好、持续时间长。

PURPOSE To investigate the efficacy of Buprenorphine in the treatment of postoperative pain.METHODS 40 postoperative patients were divided into two groups.Buprenorphine 0.3 mg was injected intramuscularly in group Ⅰ,and 0.15 mg in group Ⅱ.The effects were compared.RESULTS It was found that group Ⅰ had longer duration of analgesia than group Ⅱ.In group Ⅰ no significant differences were found before and after injection in the HR(heart rate),BP(blood pressure),SpO 2(pulse oxygensaturation),RR(respiratory rate) and VT(tidal volume).CONCLUSIONS Buprenorphine 0.3 mg may be used successfully to provided relief of severe pain after operation.