复方消化酶联合西沙必利治疗功能性消化不良的临床疗效观察

Digestive Enzymes Joint Compound Cisapride Treatment of Functional Dyspepsia Efficacy

目的评价复方消化酶与西沙必利治疗功能性消化不良的疗效及安全性方面的对比。方法将符合功能性消化不良条件316例患者随机分为复方消化酶治疗组(A组,105例)、西沙必利治疗组(B组,105例)及复方消化酶联合西沙必利治疗组(C组,105例)3组,进行4周的疗程。结果治疗结束后,A组的总有效率为54.29%,病情缓解平均时间为(8.96±2.74)d;B组的总有效率为57.14%,病情缓解平均时间为(9.01±3.15)d;C组的总有效率为88.57%,病情缓解平均时间为(3.62±2.16)d。A、B2组相比,P>0.05,差异无统计学意义;C组分别与A组、B组相比,P均<0.05,C组的疗效及病情缓解平均时间均优于A、B组,差异具有统计学意义。结论在临床的治疗工作中,如果是要快速缓解功能性消化不良症状可选用复方消化酶联合西沙必利治疗,且无明显不良反应。

Objective To evaluate the combination of digestive enzymes and cisapride treatment of functional dyspepsia and safety aspects of the comparison.Methods Meet the conditions of 316 cases of functional dyspepsia were randomly divided into the compound of digestive enzymes treatment group （A group, 105 cases）,cisapride （B group,105 patients） and digestive enzymes in the joint compound cisapride treatment group （C group,105 patients） three groups,the 4--week course of treatment.Results After treatment,A group of the total effective rate was 54.29% ,the average remission time was （8.96±2.74）d;B group,the total effective rate was 57.14%, the average remission time was（9.01±3.15）d;C group,total effective rate of 88.57%,the average remission time was（3.62±2.16）d.A,B two groups,P〈0.05,the difference was not statistically significant;C respectively and A,B group,respectively,P〈0.05,C group,the average remission time of efficacy and are better than A,B group,the difference was statistically significant.Conclusion The clinical treatment of work,if it is to rapidly alleviate the symptoms of functional dyspepsia,digestive enzymes can use joint compound cisapride treatment,and no significant adverse reactions.