软珊瑚Sarcophyton tortuosum共生真菌Penicillium sp.的代谢产物研究

The Metabolites of the Marine Fungus Penicillium sp. Associated with Soft Coral Sarcophyton tortuosum

从三亚采集的软珊瑚Sarcophyton tortuosum体内分离得到一株共生真菌Penicillium sp.,该菌在GPY培养基中培养,菌体呈浅红色。对该菌菌体的代谢产物进行了研究,纯化得到1个新化合物:(4E,6E)-2-N-十六碳酰基-1,3-二羟基十六烷-4,6-二烯-鞘胺醇(1),以及4个已知化合物1,7-二羟基-3-甲氧基-6-甲基-蒽醌(2),1,7,8-三羟基-3-甲氧基-6-甲基-蒽醌(3),1-羟基-3-甲氧基-6-甲基-蒽醌(4),4,8-二甲基-1,5-二氧环辛烷-2,6-二酮(5)。化合物结构主要通过MS,NMR等波谱数据分析确定。化合物2,3,4,5为首次从海洋真菌中分离得到。

Marine fungus Penicillium sp.was isolated from the soft coral Sarcophyton tortuosum collected in the South China Sea.While cultured in GPY medium,the fungal mycelia were reddish.Five compounds including（4E,6E）-2-N-hexadecanoyl-1,3-dihydroxyhexadeca-4,6-dien-sphingosine（1）,1,7-dihydroxy-3-methoxy-6-methyl-anthraquinone macrosporin（2）,1,7,8-trihydroxy-3-methoxy-6-methyl-anthraquinone（3）,1-hydroxy-3-methoxy-6-methyl-anthraquinone（4） and 4,8-dimethyl-1,5-dioxocane-2,6-dione（5） were obtained from the methanol extract of the fungal mycelia.Their structures were characterized by MS and NMR analyses.The result indicated that the compound（1） was a new compound,and the compounds 2,3,4,5 were first isolated from the marine fungus.