窒息新生儿应激状态下内分泌改变及临床意义

The Endocrine Change and Clinical Significance of the Asphyxiated Newborns in Stress

目的 研究窒息新生儿应激状态下内分泌改变以指导临床抢救及判断预后。方法 检测３８例新生儿血中Ｔ３、Ｔ４、胰岛素、皮质醇水平，实验组为２０例窒息新生儿，对照组为１８例新生儿肺炎和上呼吸道感染患儿。结果 实验组Ｔ３、Ｔ４低于对照组（Ｐ＜０．０１），而胰岛素、皮质醇水平高于对照组（Ｐ＜０．０１）。结论 Ｔ３和皮质醇可作为判断窒息新生儿预后的指标，持续监测窒息新生儿的内分泌变化可以提供判断预后的证据，还可及时采取相应正确的治疗措施以减少应激反应对机体的损害。

Object To study the endocrine change of the asphyxiated newborns in stress and guide the clinical rescue and decide prognosis better.Method:T3.T4.insulin.cortisol were examined in 38 newborns.20 asphyxiated newborns into experiment gorup.18 neonatal pneumonias and upper respiratory infections into control group.Result:T3.T4 in experiment group were lower than control group(P<0 01),but insulin and cortisol in experiment group were higher than control group(P<0 01).Conclusion:T3 and cortisol may be the index to decide prognosis of the asphyxiated newborns,Continual monitor endocrine change of the asphyxiated newborns may provide the evidence to decide prognosis,but also it may take the correct treatment promptly to reduce injury induced by stress.