ICA在糖尿病诊疗中的应用研究

A Study of Islet Cell Antibodies in the Therapy and Diagnosis of Diabetes

用免疫酶法分析了糖尿病患者及甲状腺疾病患者血清中的胰岛细胞抗体(ICA)的水平,结果为经胰岛素吸收后,IDDM组阳性率为467%(最高),NIDDM组阳性率为133%,甲状腺疾病组(其中1例Graves’病伴糖尿病ICA阳性)阳性率为4%,健康组为0统计学分析,P<005,具有显著性差异,表明ICA是I型糖尿病的特异性免疫标志物,ICA检测作为对IDDM与NIDDM的鉴别诊断,特别是对LADA糖尿病患者的鉴别诊断具有重要意义。

Islet cell antibodies (ICA) were evaluated using standard ABC methods (Immunolabelling). The statistical analysis shows that the positive rate of ICA of IDDM is the highest after resorption of insulin. The positive rate of IDDM, NIDDM, thyroid disease,healthy person was respectively 46 7%, 13 3%, 4%, 0 respectively( P <0 05). There ws notable difference. The data presented in this report show that ICA is specificity antibody in IDDM. ICA determination is especially important in distinguishing IDDM and LADA from NIDDM.