原发性高血压患者血浆PⅢNP含量的变化

Alteration of plasma PⅢNP concentration in patients with essential hypertension

目的:了解原发性高血压患者型胶原代谢情况,以及血浆型胶原的N末端肽(PNP)含量与左心室功能参数之间的关系。方法:采用放射免疫分析方法测定了50例原发性高血压患者及26例正常人血浆PNP含量,以二维M型多普勒超声心动图检测所有观察对象的左心室收缩和舒张功能。结果:高血压组血浆PNP含量明显高于正常对照组(P<0.01);原发性高血压期和期患者血浆PNP含量明显高于原发性高血压期患者及正常人(P<0.05)。高血压患者血浆PNP含量的增加明显与其左心室舒张功能减退有关,而与左心室收缩功能减退似无关。结论:原发性高血压患者型胶原代谢明显增强,血浆PNP含量与左心室舒张功能减退明显相关,提示型胶原参与了左心室泵衰竭的发生过程。

Objective: To evaluate fibrogenic activity of collagen type Ⅲ in patients with essential hypertension (EH) and to assess whether some relation exists between the plasma concentration of PⅢNP and several parameters of left ventricular function. Methods: Plasma PⅢNP concentration was measured by radioimmunoassay in 50 patients with essential hypertension and in 26 normal control subjects.Two dimensional,targeted M mode and Doppler ultrasound recordings were obtained in every subject to determine several parameters of the left ventricle function. Results: Baseline plasma PⅢNP was increased in hypertension group as compared with normotensive control group( P <0.01); Plasma concentration of PⅢNP was significantly higher in the patients of hypertension phase Ⅱ and Ⅲ than in those of phase Ⅰ and the normotensive ( P <0.05).Plasma PⅢNP concentrations were inversely correlated with the parameters of left ventricular diastolic function, but it is not related with the impairment of left ventricular systolic function. Conclusion: Tissue synthesis of collagen type Ⅲ is increased in essential hypertension. An obvious correlation is found between plasma PⅢNP and diastolic functional impairment of the hypertensive left ventricle, suggesting that collagen type Ⅲ plays a role in left ventricular pump dysfunction.